Molecular mechanisms of development of cellular insulin resistance

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The biological actions of insulin are initiated by activating its membrane receptor, which triggers multiple signaling pathways to mediate their biological actions. Due to the importance of metabolic regulation and promoting functions of cell growth and proliferation, insulin actions are highly regulated to promote proper metabolic functioning and energy balance. If these mechanisms are altered...

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Molecular Mechanisms of Insulin Resistance in Chronic Kidney Disease

Insulin resistance refers to reduced sensitivity of organs to insulin-initiated biologic processes that result in metabolic defects. Insulin resistance is common in patients with end-stage renal disease but also occurs in patients with chronic kidney disease (CKD), even when the serum creatinine is minimally increased. Following insulin binding to its receptor, auto-phosphorylation of the insul...

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ژورنال

عنوان ژورنال: Biopolymers and Cell

سال: 2011

ISSN: 0233-7657,1993-6842

DOI: 10.7124/bc.000106